Liquid Dosage
A fermentation starter or starter culture is a preparation that’s used to kick-start the fermentation process in a number of diverse industries, from food & renewables to biotechnology and pharmaceutical.
In the pharmaceutical industry, bacteria are used to produce antibiotics, vaccines and medically useful enzymes. The biotechnology industry uses bacterial cells for the production of biological substances that are useful to human existence, including fuels, foods, medicines, hormones, enzymes, proteins and nucleic acids, resulting in the development of human hormones such as insulin, enzymes such as streptokinase, and human proteins such as interferon and tumor necrosis factor. These products are used for the treatment of a various medical conditions and diseases, including diabetes, heart attack, tuberculosis, AIDS and SLE (lupus).
Starter cultures are derived from undefined, empirically produced species to attain an end-product with predictable and reproducible quality and quantity characteristics. The production of starter cultures can be divided into two sections.
After fermentation, the bacteria must be processed and separated from the fermentation solution, comprising the cultured micro-organisms and the remainder of the nutrient solution. First, the bacteria are separated from the liquid phase and concentrated: nozzle and self-cleaning steam-sterilizable disc separators are available for this step of the process.
The concentrated culture is then transferred to a freeze dryer (lyophilizer) and dried. Finally, the cultures are packaged under airtight conditions and stored at low temperatures.
The careful treatment of the active culture, sterility and high separation efficiencies are prerequisites for the economical, reliable and efficient processing of bacterial starter cultures. As such, separators from GEA are equipped with hydrohermetic product feed systems that minimize the shear forces experienced when the product enters the bowl, which maintains the viability of the cells.
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Aseptic valves face exceptionally high demands within UltraClean and Aseptic processes. You can be assured that they all provide highest quality in terms of hygienic design and sustainability.

GEA'nın yenilikçi CIP konseptleri, kapsamlı yüksek standartları karşılamaktadır. Uzmanlarımız, prosesin her noktasında ürün güvenliğini garanti etmektedir. Her bir iyileştirme işlemi, yerel şartlara ve müşteri gerekliliklerine adapte edilir ve farkedilebilir tasarruflar sağlar.

GEA Endüstriyel homojenizatörleri, iki temel elemanla yapılmış makinelerdir: ürünün yüksek basınçta pompalanmasını sağlayan bir sıkıştırma bloku ve dağılan partikülleri ürün karakteristiklerine ve istenilen sonuçlara göre sırasıyla mikrometre ve nanometre boyutuna mikronlaştıran bir homojenizasyon vanası.

GEA Hilge, içecek, gıda ve ilaç endüstrilerinde çok çeşitli hassas uygulamalar için çok yönlü santrifüjlü ve pozitif deplasmanlı pompalar sunmaktadır.

Whether it’s a fad or the future, 100% vial traceability is becoming an increasingly important consideration in the pharmaceutical freeze drying industry. Keeping a close eye on developments is GEA. We’re investigating possible solutions and, what’s more, we have the experience, expertise and know-how to implement them.

'Alkolsüz bira' ve 'güzel tat' ifadelerinin özellikle tüketiciler tarafından nadiren aynı cümlede kullanıldığı zamanlar vardı. Ancak düşük dereceli ve alkolsüz biralar uzun bir yol katetti - büyük bir çoğunluğu GEA'nın küçümsenemeyecek teknolojisi sayesinde artık kendi sınıflarında ferahlatıcı bir içecek haline geldi.

At GEA, our commitment to engineering for a better world fuels our pursuit of innovative solutions that enhance patient care and safety. One of our most promising ventures in recent years is aseptic spray drying – a technology that promises to revolutionize pharmaceutical manufacturing.