Liquid Dosage
Hormones & Steroids
Steroids, endogenous hormones such as the sex hormones estrogen and testosterone or the hormones of the adrenal cortex, cortisol and aldosterone, play a key role in metabolic processes and have a number of pharmaceutical applications, including hormone therapy, anti-rheumatic, anti-arthritic and bodybuilding preparations.
Mainly used in the global hormone replacement therapy, currently worth about $3.6 billion, the three major segments comprise estrogen, growth and thyroid hormone, and testosterone replacement therapy. A major market driver is the increased awareness of postmenopausal hazards amongst women; others include an ageing population, innovative drug delivery systems and the pharmerging economies.
Predominantly based on cholesterol, steroid hormones are synthesized in the endocrine glands and transported to target tissue by the blood. At their site of action, they dock with highly specific cellular receptors and perform a key function in protein formation. To produce steroid hormones for pharmaceutical applications outside the body, a direct extraction procedure from special nutrient solutions is used.
Counter-Current Liquid-Liquid Extraction
In continuous direct extraction from GEA, the fermented nutrient solution is treated by liquid-liquid extraction in a counter-current process. Following precipitation, concentration, crystallization and drying of the extract, the steroid hormones are available in the form of a raw salt and can be correspondingly processed by the pharmaceutical industry. In a continuous direct extraction process, the fermented nutrient solution undergoes a counter-current liquid-liquid extraction process (also known as also known as solvent extraction or partitioning). Following precipitation, concentration, crystallization and drying, the extracted steroid hormones are available in the form of a raw salt and can be subsequently processed by the pharmaceutical industry.
Fromfacility design and layout, manufacturing process controls (including adherence to standard operating procedures) and environmental control systems (HVAC) to extraction systems, industrial hygiene solutions and fully integrated, end-to-end containment solutions, GEA has the experience and know-how to implement and optimize end-to-end production lines for steroid- and hormone-based applications.
Produits et technologies
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Hygienic pumps
GEA Hilge offre une gamme polyvalente de pompes centrifuges et de pompes volumétriques positives pour un large éventail d'applications sensibles dans les industries des boissons, agroalimentaire et pharmaceutique.
Lyophilizers (Pharma Freeze Dryers)
GEA's thorough understanding of the lyophilization process enables them to supply a comprehensive range of products and services, comprising laboratory equipment, pilot plants for research and small-scale production batches, industrial size pharmaceutical production freeze dryers.
R&D Drying Systems
GEA's versatile range of R&D drying & particle processing equipment - for advanced powder processing within food and dairy products, chemicals and pharmaceuticals.
Solutions NEP/SEP
Les concepts NEP innovants de GEA répondent à des normes strictes et complètes. Nos experts garantissent la sûreté du produit à chaque étape du processus. Chaque mise à niveau est adaptée aux conditions locales particulières et aux exigences du client, et permet de réaliser des économies notables.
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GEA Insights
All pharmaceutical freeze-drying vials are the same! Aren't they?
Whether it’s a fad or the future, 100% vial traceability is becoming an increasingly important consideration in the pharmaceutical freeze drying industry. Keeping a close eye on developments is GEA. We’re investigating possible solutions and, what’s more, we have the experience, expertise and know-how to implement them.
Bière sans alcool : Ils en veulent tous – avec moins
Autrefois les expressions « bière sans alcool » et « c’est bon » étaient rarement utilisées ensemble dans la même phrase, en particulier par les consommateurs. Mais depuis les bières à faible teneur en alcool et sans alcool ont fait bien du chemin et nombreuses d’entre elles ont désormais accédé au rang de boissons rafraîchissantes à part entière, et ce, en grande partie grâce à la technologie de GEA.
Innovating patient care with aseptic spray drying
At GEA, our commitment to engineering for a better world fuels our pursuit of innovative solutions that enhance patient care and safety. One of our most promising ventures in recent years is aseptic spray drying – a technology that promises to revolutionize pharmaceutical manufacturing.
